Bone Morphogenetic Proteins Induce Astroglial Differentiation of Oligodendroglial–Astroglial Progenitor Cells
نویسندگان
چکیده
منابع مشابه
Bone morphogenetic proteins induce astroglial differentiation of oligodendroglial-astroglial progenitor cells.
We have used bipotent postnatal cortical oligodendroglial-astroglial progenitor cells (O-2As) to examine the role of inductive signals in astroglial lineage commitment. O-2A progenitor cells undergo progressive oligodendroglial differentiation when cultured in serum-free medium, but differentiate into astrocytes in medium supplemented with FBS. We now report that the bone morphogenetic proteins...
متن کاملBone Morphogenetic Proteins Promote Astroglial Lineage Commitment by Mammalian Subventricular Zone Progenitor Cells
The epigenetic signals that regulate lineage development in the embryonic mammalian brain are poorly understood. Here we demonstrate that a specific subclass of the transforming growth factor beta superfamily, the bone morphogenetic proteins (BMPs), cause the selective, dose-dependent elaboration of the astroglial lineage from murine embryonic subventricular zone (SVZ) multipotent progenitor ce...
متن کاملBone Morphogenetic Proteins and Adipocyte Differentiation
Bone morphogenetic proteins (BMPs) regulate many processes during embryogenesis and morphogenesis. However, the role of this family of proteins in adipogenesis appears to be underappreciated in the field of developmental biology. In the past fifteen years, our concept of adipose tissue has undergone a radical transformation: initially viewed as an inert mass for energy storage, adipose tissue i...
متن کاملRole of bone morphogenetic proteins in cardiac differentiation.
Bone morphogenetic proteins (BMP) are involved in the regulation of a plethora of processes underlying cardiovascular development. This review summarizes the effects of BMP and the signaling pathways that regulate the differentiation of cardiomyocytes from mesoderm in the heart-forming region and at the distal borders of the heart tube from the second heart field. Subsequently, the role of BMPs...
متن کاملBone morphogenetic proteins induce apoptosis in human pulmonary vascular smooth muscle cells.
Pulmonary vascular medial hypertrophy in primary pulmonary hypertension (PPH) is mainly caused by increased proliferation and decreased apoptosis in pulmonary artery smooth muscle cells (PASMCs). Mutations of the bone morphogenetic protein (BMP) receptor type II (BMP-RII) gene have been implicated in patients with familial and sporadic PPH. The objective of this study was to elucidate the apopt...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Neuroscience
سال: 1997
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.17-11-04112.1997